Layout a illustrated design

[limetouch]

I am sure you have heard of the very beautiful illustrated designs. I have got my designer to design one of those for me for my latest blog theme, I just need to turn that design into a WordPress theme.

However this is my first in laying out an illustrated design in CSS. I am curious, how would you do it since nothing is quite uniform and structured? I am thinking in relative positioning all the way.

Hope to get your guys input on this.